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Atorvastatin Calcium CAS NO.134523-03-8
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Product: Views:462Atorvastatin Calcium CAS NO.134523-03-8 
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Last updated: 2019-07-29 16:13
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Atorvastatin calcium Basic information

Product Name:

Atorvastatin calcium

Synonyms:

Atorvastatin Calcium Anhydrous;Calcium of atorvastatin;Atorvastatin ;Atorvastatin aMorphous;atorvastatine calciuM salt;(βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole-1-heptanoic Acid CalciuM Salt;Atorvastatin HeMicalciuM;Sortis

CAS:

134523-03-8

MF:

C66H68CaF2N4O10

MW:

1155.36

EINECS:

200-659-6


Atorvastatin calcium Chemical Properties

Melting point

176-178°C

storage temp.

Store at +4°C

solubility

DMSO: ≥10mg/mL

form

white powder


Atorvastatin calcium Usage And Synthesis

Mode of action

Atorvastatin takes effect through selectively and competitively inhibiting the hepatic enzyme HMG-CoA reductase, which is responsible for converting HMG-CoA to mevalonate in the cholesterol biosynthesis pathway. This results in a subsequent decrease in hepatic cholesterol levels. Decreased hepatic cholesterol levels stimulates upregulation of hepatic LDL-C receptors which increases hepatic uptake of LDL-C and reduces serum LDL-C concentrations.

Chemical Properties

White Crystalline Powder

Uses

The primary uses of atorvastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease.


Atorvastatin calcium Specification

Character

A white or almost white?crystalline powder

Identification

A: IR.
B: CALCIUM

water

3.5~5.5

Ca %

3.0~3.6

Particle size

D90≤10 µm

Heavy Metals(ppm)

≤20

Impurity
(HPLC)

Impurity E

≤0.3%

Impurity A

≤0.3%

Impurity?B

≤0.3%

Impurity C

≤0.3%

Impurity D

≤0.1%

Other individual unknown Impurity %

≤0.1%

Total impurity

≤1.0%

Assay %

98.0-102.0

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